07/25/2002
Rx: Just a Tad of Poison
"The poison is in the dose." This profound statement was brought to mind last week when I saw a news report on what went wrong when some women opted for Botox injections at a substantial discount to the going rate for the plastic surgery. One woman''s body was shown covered with ugly scars, blisters and infected lesions resulting from the injections. It turns out the surgery was performed by "plastic surgeons" who were no such thing. I didn''t catch whether or not the bogus practitioners used real Botox.
The TV report reminded me of a brief article in the July 2002 issue of Discover magazine. The article, by Susan Freinkel, was titled "New Remedies from Old Poisons" and contained the quote I used to open this column. Freinkel attributed the quote to the "Renaissance physician and apothecary" Paracelsus. I thought to myself that Paracelsus was one cool dude to have made that observation about dosage and poison way back in the 1500s. Botox is a prime example where the dosage makes the difference between a poison and a therapeutic drug.
Even water can be dangerous in too large a dose. We''re continually admonished to drink 8 glasses a day or equivalent of the stuff. And on hot, sticky days like today (I had to quit after nine holes), avoiding dehydration is a "good thing", as Martha would say. However, in the Discover article Freinkel cited a recent study of marathon runners who became deathly ill after their races. The study found that the cause of their distress was too much water. Because of the dilution of salt in their blood, there was a buildup of fluid in their lungs and brain! Paracelsus was right, dosage matters.
Back to Botox, the approval by the FDA of it''s use to treat frown lines in April this year spurred a huge demand for injections from the wrinkled masses. Botox works by inhibiting the release of a compound known as acetylcholine, which signals muscles to contract. Injection into the frown line muscles essentially paralyzes them so they can''t contract and the frown is gone, if all goes as expected. Yet, the botulinum toxin in Botox in doses some 70 times higher could result in botulism and erase you along with your frown lines! As for myself, I''m going to live with all my wrinkles and sags.
Aside from such cosmetic uses, there are apparently other, more pressing medical applications of Botox given in small-doses. In addition to cerebral palsy, Parkinson''s, migraines and other conditions, one that I found interesting was in treating what might well have been called the Ed Sullivan disease. We all watched Ed Sullivan in the early days of TV; you can still see his syndicated shows on Public TV. Judging from the article, Ed had what is known as cervical dystonia, a condition in which the neck is frozen at an uncomfortable angle. In Sullivan''s case, his rather odd posture was somewhat of a trademark and provided material for comedy routines. Botox might have straightened up poor Ed.
Arsenic and its compounds are well known poisons. In the play "Arsenic and Old Lace", two lovable spinsters make a practice of feeding arsenic-laced delicacies to unsuspecting men. In real life, India has a huge problem with too much arsenic in the drinking water in certain areas of that country. Here in the U.S., Christie Whitman and the EPA have been under fire by environmentalists for not instituting stricter limits of the amount of arsenic allowable in our own drinking water. If you ingest arsenic in one big dose or repeated small doses, you''re likely to experience the same fate those fellows in the play suffered at the hands of those spinsters. Surprisingly, Freinkel cites the case of some people in Austria who have claimed that arsenic has a tonic effect. These adventurous souls built up such a tolerance for arsenic that they could ingest repeated doses that would kill you and me.
Along these lines, Freinkel cites the use of arsenic trioxide in treating a lethal form of leukemia known as promyelocytic leukemia. She cites a study of some 52 patients given a third of the dose of arsenic trioxide that would kill them. Almost 90 percent of the patients went into remission and half were still alive two years later. It seems that instead of killing cells as does standard chemotherapy, the arsenic compound targets a protein that stops white cells from normal development. It''s the abnormal development of the white cells that results in leukemia.
Freinkel discusses other examples of Paracelsus'' truism. For example, pure nicotine in doses as small a ten thousandth of an ounce will put you six feet under. Yet patches of nicotine have been used to treat maladies such as Tourette''s syndrome, Alzheimer''s (I should hasten to add, it''s not a cure), attention deficit disorder and even schizophrenia. Another example is the venom from a type of cone snail that uses its venom to paralyze passing fish. Injected into humans it''s much more potent than morphine as a painkiller.
I wasn''t familiar with Paracelsus and decided to check him out a bit further. I ended up consulting the International Encyclopedia of Science and Technology", my Encarta 97 Encyclopedia, my World Book Encyclopedia, a Catholic Encyclopedia Web site (newadvent.org), a Rice University Web site and a site (dbhs.wvusd.k12.ca.us) whose origin is unknown to me. Why all these sources? I was simply trying to find out the guy''s name!
One source has the "Swiss physician" Paracelsus starting out life in Switzerland in 1493 with the name Phillipus Aureolus Theophrastus Bombastus von Hohenheim. (Other sources describe him as a German. As best I can determine, Switzerland as such was still in the process of being invented in the 1490s.) Various sources have different versions of his name involving all sorts of permutations and combinations of some or all of the above names. No wonder he adopted the pseudonym of Paracelsus. I''m only sorry that when I picked out my own pseudonym I hadn''t read about him. The name Theophrastus Bortrum would have been much more impressive!
One thing for sure, Paracelsus was a controversial character, aside from his name. He seems to have offended just about everyone he met. One source suggests that he either died in a drunken stupor or was thrown down a flight of stairs by envious apothecaries! Another source says that reports of his drinking were untrue and that he died of natural causes, albeit he was only 48 years old when he died.
Why is Paracelsus important? He is generally given the credit for altering the course of medicine. How? He not only questioned the 1400 year old works of the Greek physician Galen and the Arab Avicenna, he publicly burned their works to express his disdain. For 500 years, Avicenna''s "The Canon of Medicine" had been the standard medical text throughout the Middle East and Europe. Paracelsus thought that disease was not caused by imbalances in the body "humors", as was the prevailing belief from Galen''s time in Greece. Paracelsus said instead that disease arose from outside causes for which he described remedies. For example, he prescribed mercury for the treatment of syphilis and would prescribe "essences" and "tinctures" for various maladies. Whether or not these remedies worked, he seems to be the one we should credit for initiating the the modern era of therapeutic measures to cure and prevent disease.
Although Paracelsus is described as a physician, sources disagree on whether or not he ever actually received a medical degree. There''s no doubt that he was an alchemist. He considered the body to be composed mostly of salt, sulfur and mercury and introduced such things as mercury, lead and opium into the pharmacist''s catalog of remedies. I perused one of his purported writings on one of the cited Web sites. It was pure fantasy, with weird, totally incomprehensible instructions for such things as turning mercury into silver and gold and other alchemy.
Whatever his faults, Paracelsus shook up the medical establishment of his time and paved the way for more wide ranging studies of diseases, their causes and treatments. And today, poison is even more truly in the dose.
Allen F. Bortrum
|