12/12/2007
Travelers - Animal and Cosmic
In my November 9 issue of Science, I found three articles that provide follow-up material on subjects I wrote about in past columns. These articles related to the decoding of the genome of drug-resistant strains of tuberculosis, to the origin of cosmic rays and to the subject of last week’s column, the “inner compass” that provides guidance to birds, fish and other animals in their travels.
MRSA and drug-resistant TB are two medical problems of great concern these days. Researchers at the Broad Institute and Harvard School of Public Health have sequenced most of the genome of an extensively drug-resistant TB strain as part of an international effort to decode the genomes of various drug- resistant and drug-sensitive TB bacteria. The Broad-Harvard team finds that there are roughly 30 or so mutations in the drug- resistant TB genome compared to the genome of old fashioned TB that is treatable with drugs. This relatively small number of mutations holds out the hope that it should be a less daunting task to identify those mutations that confer drug resistance and come up with a drug or drugs to treat drug-resistant TB. Of course, this will involve developing new diagnostic tools and drug R&D is not a speedy process. We’re talking years here but at least it should be feasible.
Turning to cosmic rays, which enter the Earth’s atmosphere from all directions, there’s been an ongoing quest for decades to find the source. Of particular interest have been the really high- energy cosmic rays, which really aren’t “rays” as we think of them, but are particles. If you’re sitting with a cosmic ray detector waiting to catch a super high-energy cosmic ray, you’d better have a lot of patience – or a slew of detectors that cover a lot of area. Here we’re talking cosmic rays that have the energy equivalent to a good size hailstone. This may not impress you but chances are this cosmic ray is actually just a single proton, a hydrogen atom without its electron. Physicists talk about cosmic rays having energies expressed in terms of electron-volts (eV). At the low end, at only a hundred billion eV or so, a few of these particles strike an area of a square centimeter in the Earth’s atmosphere every second.
On the other hand, at the super high-energy end, at a hundred billion billion eV (that’s 1 followed by 20 zeroes!), there may be only one particle hitting a square kilometer in a century or more! That’s a long time to wait. Enter the Pierre Auger Southern Observatory in western Argentina. The observatory consists of 1600 surface detectors spread out over an area roughly the size of Rhode Island (3,000 square kilometers). The observatory has been in operation since 2004 and has recorded a million cosmic ray events in that time. Of the million, only 80 have had energies over 40 billion billion eV, the super high-energy particles of interest. The Pierre Auger Collaboration of several hundred authors (!) from 89 different institutions worldwide report their results in an article titled “Correlation of the Highest-Energy Cosmic Rays with Nearby Extragalactic Objects”.
Well, their definition of “nearby” may seem a stretch – the nearby objects are roughly 250 million light-years away; that’s over a billion trillion miles! For these super high-energy particles to have made their way over such vast distances without losing energy is remarkable and the new data and analysis of older results now indicate the likely source to be what are known as “active galactic nuclei” (AGN). An AGN is a galaxy that has a black hole that is busy gobbling up gas and stars and ejecting vast plumes of plasma into the space between galaxies. If AGNs are indeed the source, these cosmic “hailstones” have had a remarkable journey indeed!
Finally, last week we talked about migrating songbirds and their having some kind of inner compass to guide them on their way. In that column, I didn’t mention what that inner compass might consist of. However, I do recall discussing on at least one occasion the view that birds and fish depend on tiny magnetite crystals in their beaks or noses to determine their position with respect to the earth’s magnetic field. An early proponent of the magnetite compass was Michael Walker who, with Joseph Kirschvink of the California Institute of Technology, published a paper in Science in 1984 reporting the discovery of magnetite- like crystals in tuna.
Later, in 1997 and 2000, Walker and other colleagues published papers in Nature reporting the discovery of strings of magnetite crystals in the noses of rainbow trout. However, at about the same time a compound called cryptochrome was found in the eyes of all sorts of animals ranging from fruit flies to mice. The interesting thing about cryptochrome is that when light strikes it there are two intermediate states formed and the relative amounts of the two intermediates depends on the orientation of the animal with respect to the surrounding magnetic field.
The finding of cryptochrome has led to the suggestion that information about the amounts of these two intermediate states is transmitted to the brain from the eyes via the optic nerves. This in turn has led to the postulate that birds can actually “see” the magnetic field of the earth by turning their heads one way or the other. If true, how the magnetic field information would register in the brain is up in the air. Walker is quoted as saying the idea of evolution coming up with two organs for sensing the magnetic field is absurd. The cryptochrome camp includes John Phillips at Virginia Polytechnic Institute and Henrik Mouritsen at the University of Oldenburg in Germany. They maintain the evidence favoring the involvement of cryptochrome in sensing a magnetic field is just as good as the evidence for magnetite.
Mouritsen and Phillips hope to settle the question by experimenting with mice in which the cryptochrome has been genetically engineered out of the picture. What the experiments will be wasn’t mentioned but I imagine one experiment will be to compare the performance of normal mice with the performance of knockout mice in mazes.
Whatever the results, I would expect that in another year or so we’ll know a lot more definitely how animals find their way, sometimes over thousands of miles. Meanwhile, as far as our own species is concerned, we males will probably continue to be chastised by our wives or significant others for being stubborn and not asking directions.
Allen F. Bortrum
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