04/09/2008
Detect NO, Breathe Better
Two subjects that I’ve visited a number of times in these columns over the years are nitric oxide and carbon. My first column dealt with nitric oxide, NO, and its role in the dilation of blood vessels, an important aspect of the effect of the drug Viagra. Nitric oxide has since been shown to be a key player in many processes in our bodies. For those afflicted with asthma, NO may be a mixed blessing. Preceding an asthmatic attack, the airways become inflamed. Accompany the inflammation is an increase in the production of NO, which shows up in the breath as much as one to three weeks prior to an attack. The NO may help in some way to fight the inflammation while at the same time it may spur other bodily reactions that aggravate the asthmatic symptoms. One good thing is that if this increase in NO is detected early, preventative medications can be taken to prevent or minimize the severity of the upcoming attack.
Carbon, of course, is the basic element in organic chemistry and hence in the chemistry of life itself. However, in past columns I’ve mainly been concerned with the fact that the element carbon has been found to come in many different forms other than the most familiar, diamond and graphite. One of the most interesting forms is the single walled carbon nanotube (SWNT). An SWNT is a hexagonal structure much like a piece of chicken wire rolled up into a tube, with carbon atoms arranged in the hexagons characteristic of chicken wire. The single-walled nanotube is only one atom thick and is really tiny, roughly a hundred thousand or so times thinner than the proverbial human hair.
The Winter 2008 issue of Pitt Magazine cites the work of Alex Star, an associate professor in the University of Pittsburgh’s chemistry department, where I got my doctorate in 1950. Star and his team of researchers have taken the carbon SWNT and created a device that could eventually prove very important in combating asthmatic attacks. The short article by Sam Ginsburg in the Pitt publication cites the case of Pittsburgh Steeler star running back Jerome Bettis, who some ten years ago found himself lying on the playing field struggling to breathe. This experience led him to go on a regimen of preventive medications, which have their own side effects if taken too liberally and could have affected Bettis’ peformance. Fortunately, his performance must not have suffered too much considering that he got his Super Bowl ring not too long ago.
According to the article, the measurement of NO in exhaled breath currently involves a visit to a doctor’s office or a hospital having the required relatively large, expensive machine. The goal of Alex Star and his team was to come up with a handheld portable, reusable device the size of an inhaler that would do for asthmatics what those widely advertised glucose monitors do for diabetics. Utilizing SWNTs, they have come up with a prototype device that is being or will be clinically tested by Jigme Sethi, a professor at the University of Pittsburgh Medical Center’s Montefiore Hospital.
The extreme thinness of a single-walled nanotube makes the SWNT very sensitive to changes in the chemistry of its environment. The Pitt researchers have coated their SWNTs with a particular type of polymer that enhances the SWNT’s sensitivity to nitric oxide. While various accounts, including the Pitt article and various media articles, imply that only one SWNT is used in the device, it appears that the device employs a network of SWNTs. The prototype model runs on a watch battery, which sends a small current through the network. In the presence of nitric oxide, even in the parts per billion range, the current changes, thus providing the asthma patient with a warning to take measures to deal with or avoid an upcoming attack.
The Pitt work was published last August in the journal Nanotechnology and at that time the device had not yet been tested on actual patients. If the clinical trials prove successful, a manufacturer will have to be found and the FDA will have to give its blessing. Hopefully, for the sake of Bettis and the many asthma sufferers, this will all come to pass as quickly as possible.
Allen F. Bortrum
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